Research - Results
Clinical Observations and Rectal Temperatures
Figure 1: Control Group: Rectal temperatures (°F) in dogs vaccinated with water solution followed by challenge with CPV2c
Figure 2: Vaccinate Group: Rectal temperatures (°F) in dogs vaccinated with Vanguard® 7 followed by challenge with CPV2c
Following vaccination, none of the vaccinated animals showed any injection site reactions (redness, heat, pain, and/or swelling). Neither the control nor the vaccinated animals showed any signs of abnormal health following administration of water for injection or Vanguard® 7 respectively.
After challenge on day 42, control animals showed clinical signs classically associated with parvovirus. Signs started 4 days post-challenge. Due to these clinical signs of parvovirus, the control animals were removed from the study 7 and 9 days after challenge (day 49 and day 51), respectively. In contrast, vaccinated animals did not exhibit any abnormal clinical signs post-challenge. Prestudy and following administration of water for injection or Vanguard® 7, rectal temperatures of all animals fluctuated within normal limits ranging from 100.22°F to 102.74°F (Figure 1 and Figure 2).
After challenge, rectal temperatures of all animals remained normal for 3 days (Figure 1 and Figure 2). Four days after challenge (day 46), pyrexia was observed in control animals with temperatures of >103.1°F for one day. Rectal temperatures of control animals thereafter decreased again below 102.92°F. One control animal showed a second rectal temperature increase 8 days after challenge (day 50). In contrast, rectal temperatures of all vaccinated animals remained between 100.94°F and 102.56°F until they completed the study 14 days after challenge.
